Dipartimento di Medicina Sperimentale e Clinica "G. Salvatore", "Magna Græcia" University, Catanzaro, Italy.
Clin Hemorheol Microcirc. 2013 Jan 1;55(2):223-9. doi: 10.3233/CH-2012-1624.
The influence of lipids on blood and plasma viscosity has not been fully elucidated. In this study we evaluated the contribution of HDL cholesterol to blood and plasma viscosity, in healthy subjects.
One hundred and forty-four (80 males and 64 females) subjects were enrolled among free-living participants to a cardiovascular disease screening. Exclusion criteria were: diabetes, elevated triglycerides, elevated LDL cholesterol, smoking and drug use. Blood lipids were measured by routine methods. Blood and plasma viscosity were measured by a cone-plate viscometer (Wells-Brookfield DV-III, Stoughton, U.S.A.). Subjects were divided in two groups: at low (<50 mg/dl) and high HDL cholesterol (>50 mg/dl).
Blood and plasma viscosity were similar in subjects at low and high HDL cholesterol. In univariate analysis none of the lipid variables was significantly correlated with blood and/or plasma viscosity. In multivariate analysis only LDL cholesterol was marginally associated with blood viscosity.
HDL cholesterol does not influence blood and plasma viscosity in healthy normolipidemic subjects. LDL cholesterol is marginally associated with blood viscosity.
脂质对血液和血浆黏度的影响尚未完全阐明。本研究评估了高密度脂蛋白胆固醇（HDL 胆固醇）对健康受试者血液和血浆黏度的影响。
在心血管疾病筛查中，从自由生活的参与者中招募了 144 名受试者（80 名男性和 64 名女性）。排除标准为：糖尿病、甘油三酯升高、LDL 胆固醇升高、吸烟和药物使用。血脂采用常规方法测定。血液和血浆黏度采用锥板黏度计（美国斯托顿威尔斯-布鲁克菲尔德 DV-III）测定。受试者分为两组：低（<50mg/dl）和高（>50mg/dl）HDL 胆固醇组。
低和高 HDL 胆固醇组的血液和血浆黏度相似。单因素分析中，无任何脂质变量与血液和/或血浆黏度显著相关。多因素分析仅显示 LDL 胆固醇与血液黏度呈边缘相关。
在健康的血脂正常受试者中，HDL 胆固醇不会影响血液和血浆黏度。LDL 胆固醇与血液黏度呈边缘相关。
