Department of Medical Biology, School of Medicine, Ege University, Izmir, Turkey.
Mol Biol Rep. 2013 Feb;40(2):1591-7. doi: 10.1007/s11033-012-2207-6. Epub 2012 Oct 18.
The aim of this work was to report two cases of hypereosinophilic syndrome (HES). FIP1L1-PDGFRA fusion was assessed with two protocols at RNA level. The fusion transcript was found positive at the RNA level with both PCR methods in two cases. In this study, the efficiency of imatinib treatment and a dramatic response in two HES cases with multisystemic involvement showing the characteristics of a chronic myeloproliferative disease were presented. Both cases showed complete responses confirming that imatinib mesylate treatment could be successful even in patients with advanced HES having myeloproliferative disease.
本研究旨在报告两例高嗜酸性粒细胞综合征（HES）病例。采用两种方案在 RNA 水平检测 FIP1L1-PDGFRA 融合。两种方法的 PCR 均在 RNA 水平检测到融合转录本阳性。本研究报告了两例多系统受累的 HES 病例，表现为慢性骨髓增生性疾病特征，伊马替尼治疗的疗效和显著反应。两例均表现出完全缓解，证实即使在具有骨髓增生性疾病的晚期 HES 患者中，甲磺酸伊马替尼治疗也可能成功。
