Puntoni R, Vercelli M, Merlo F, Valerio F, Santi L
Ann N Y Acad Sci. 1979;330:353-77. doi: 10.1111/j.1749-6632.1979.tb18738.x.
The dockyards of Genoa are exposed to many known or suspect carcinogenic agents, namely, asbestos, silica, polycyclic aromatic hydrocarbons, and halogenated hydrocarbons; other possibly harmful substances are trace amounts of aromatic amines, welding smokes, paints, and lipid-removing solvents. A cohort study of causes of death of 2190 dockyard workers in Genoa was conducted between January 1, 1960 and December 31, 1975. Mortality rates were calculated for 20 different occupational categories, for which there exist different levels of exposure to noxious substances. Two control groups were selected: the general male population of Genoa and all male employees (462) of San Martino Hospital, Genoa for the same period of time. Causes of death that demonstrated significant excesses for both control groups were: cancer of the colon, excluding the rectum; cancer of the larynx; cancer of the lung, bronchus, and trachea; cancer of the kidney, urinary bladder, and other urinary organs; respiratory diseases; and cirrhosis of the liver. The data obtained from these 20 job categories revealed different types and levels of risk for various carcinogenic agents.
热那亚的造船厂面临许多已知或疑似致癌物质，即石棉、二氧化硅、多环芳烃和卤代烃；其他可能有害的物质是微量芳香胺、焊接烟雾、油漆和脱脂溶剂。1960年1月1日至1975年12月31日期间，对热那亚2190名造船厂工人的死因进行了队列研究。计算了20种不同职业类别的死亡率，这些职业类别接触有害物质的程度不同。选择了两个对照组：热那亚的一般男性人群和同期热那亚圣马蒂诺医院的所有男性员工（462人）。在两个对照组中均显示出显著超额死亡的死因有：结肠（不包括直肠）癌、喉癌、肺、支气管和气管癌、肾、膀胱和其他泌尿器官癌、呼吸系统疾病以及肝硬化。从这20个工作类别获得的数据揭示了各种致癌物质的不同风险类型和程度。
