Rheumazentrum Ruhrgebiet, Herne, Germany.
Clin Exp Rheumatol. 2012 Jul-Aug;30(4 Suppl 73):S142-4. Epub 2012 Oct 18.
Gout is a rheumatic disease resulting from deposition of uric acid crystals in tissues and fluids within the body. The pathogenesis involves underexcretion or overproduction of uric acid, a biproduct of metabolism of purines, resulting in a metabolic disorder commonly known as hyperuricaemia, has a relatively high prevalence in the population (0.5-1%, similar to rheumatoid arthritis). Patients with hyperuricaemia are at risk to develop acute gouty attacks which may be severely painful. The attacks tend to occur episodically over a few days up to a week or two, but gout may later become chronic. Different aims of therapy and management are well suited as targets of treatment, including reduction of purine intake, increased of excretion of uric acid, mobilisation of urate pools within the body, and reduction of acute and chronic inflammation through anti-inflammatory medications.
痛风是一种风湿性疾病，源于尿酸晶体在体内组织和体液中的沉积。其发病机制涉及尿酸排泄不足或生成过多，尿酸是嘌呤代谢的副产物，导致代谢紊乱，通常称为高尿酸血症，在人群中的患病率相对较高（0.5-1%，与类风湿关节炎相似）。高尿酸血症患者有发生急性痛风发作的风险，这种发作可能非常疼痛。发作通常持续数天至一周或两周，但痛风后来可能变为慢性。治疗和管理的不同目标非常适合作为治疗靶点，包括减少嘌呤摄入、增加尿酸排泄、动员体内尿酸池、以及通过抗炎药物减少急性和慢性炎症。
