Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
Bioorg Med Chem Lett. 2012 Dec 1;22(23):7261-4. doi: 10.1016/j.bmcl.2012.09.018. Epub 2012 Sep 23.
A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa.
已经合成了一系列氟化四氢吡喃并[3,2-c]色烯和二氢吡喃并[3,2-b]吡喃衍生物，并在宫颈癌细胞系（HeLa）、人乳腺癌腺癌细胞系（MDA-MB-231 和 MCF-7）和人肺泡腺癌细胞系（A549）中测定了它们的体外细胞毒性活性。化合物 4g、4k、4p 对 MDA-MB-231 表现出很强的活性，化合物 4c、4p 对 MCF-7 表现出有希望的活性，而化合物 4c、4g、4p 对 HeLa 表现出中等活性。
