高官能化吡喃并色烯和吡喃并吡喃的合成及细胞毒性评价。
Synthesis and cytotoxicity evaluation of highly functionalized pyranochromenes and pyranopyrans.
机构信息
Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500607, India.
出版信息
Bioorg Med Chem Lett. 2012 Dec 1;22(23):7261-4. doi: 10.1016/j.bmcl.2012.09.018. Epub 2012 Sep 23.
A series of fluorinated tetrahydropyrano[3,2-c]chromenes and dihydropyrano[3,2-b]pyran derivatives have been synthesized and their in vitro cytotoxic activities have been determined in cervical cancer cell line (HeLa), human breast adenocarcinoma cell line (MDA-MB-231 and MCF-7) and human alveolar adenocarcinoma cell line (A549). Compounds 4g, 4k, 4p showed a very potent activity against MDA-MB-231, and 4c, 4p showed promising activity against MCF-7, while compounds 4c, 4g, 4p showed moderate activity against HeLa.
已经合成了一系列氟化四氢吡喃并[3,2-c]色烯和二氢吡喃并[3,2-b]吡喃衍生物，并在宫颈癌细胞系（HeLa）、人乳腺癌腺癌细胞系（MDA-MB-231 和 MCF-7）和人肺泡腺癌细胞系（A549）中测定了它们的体外细胞毒性活性。化合物 4g、4k、4p 对 MDA-MB-231 表现出很强的活性，化合物 4c、4p 对 MCF-7 表现出有希望的活性，而化合物 4c、4g、4p 对 HeLa 表现出中等活性。
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