Department of Nanotechnology, Faculty of Pharmacy Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran.
Nanoscale. 2012 Dec 7;4(23):7322-5. doi: 10.1039/c2nr31657a.
Since amyloid beta fibrillation (AβF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Aβ fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AβF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AβF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media).
our results revealed that GO and their surface proteins inhibit AβF by decreasing the kinetic reaction.
由于淀粉样蛋白纤维（AβF）在神经退行性疾病的发展中起着重要作用，我们研究了氧化石墨烯（GO）及其蛋白覆盖表面对水溶液中 Aβ 纤维形成动力学的影响。我们表明，GO 和它们的蛋白覆盖表面通过吸附淀粉样蛋白单体来延迟 AβF 过程。此外，GO 片的大表面积可以通过吸附淀粉样蛋白单体来延迟 AβF 过程。当我们将浓度从 10%（体外；刺激介质）增加到 100%（体内；刺激介质）时，GO 片的抑制作用增强。
我们的结果表明，GO 和它们的表面蛋白通过降低动力学反应来抑制 AβF。
