Ahmadinejad Minoo, Roushan Nader
Blood Coagul Fibrinolysis. 2013 Jan;24(1):97-9. doi: 10.1097/MBC.0b013e328359bc59.
An 82-year-old man referred to our medical ward because of epistaxis and melena was found to have 12 Bethesda units of factor V inhibitor. He was managed for bleeding with supportive care, followed by corticosteroid therapy. The bleeding completely stopped 1 week after corticosteroid therapy. Medical history revealed dysphagia during the past 6 months and further evaluation brought to light a squamous cell carcinoma (SCC) in the esophagus. This is the first case of an acquired factor V inhibitor developing in a patient with esophageal SCC without any other risk factors such as surgery.
一名82岁男性因鼻出血和黑便被转诊至我院内科病房，检查发现其有12 Bethesda单位的Ⅴ因子抑制剂。对其进行了支持性治疗以控制出血，随后给予皮质类固醇治疗。皮质类固醇治疗1周后出血完全停止。病史显示患者在过去6个月中有吞咽困难，进一步检查发现食管鳞状细胞癌（SCC）。这是首例在无手术等其他危险因素的食管SCC患者中发生获得性Ⅴ因子抑制剂的病例。
