硝基精氨酸抑制内皮源性舒张。
Nitroarginine inhibits endothelium-derived relaxation.
作者信息
Kobayashi Y, Hattori K
机构信息
Department of Pharmacology, Shimane Medical University, Izumo, Japan.
出版信息
Jpn J Pharmacol. 1990 Jan;52(1):167-9. doi: 10.1254/jjp.52.167.
Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 10(2) microM NO2Arg was reduced to 10.1 +/- 4.3% (n = 5). L-arginine (10(2) microM) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO2Arg. These results indicate that NO2Arg is a novel inhibitor of endothelium-derived relaxation.
研究了胍基硝基精氨酸衍生物NG-硝基-L-精氨酸（NO2Arg）对乙酰胆碱诱导的兔胸主动脉环标本舒张的影响。乙酰胆碱引起的舒张被NO2Arg剂量依赖性抑制，10(2)微摩尔/升的NO2Arg使最大舒张率降至10.1±4.3%（n = 5）。L-精氨酸（10(2)微摩尔/升）不影响乙酰胆碱诱导的舒张。硝酸甘油或罂粟碱引起的舒张不受NO2Arg影响。这些结果表明，NO2Arg是一种新型的内皮源性舒张抑制剂。
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