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[血管化气管移植的创建]

[The creation of a vascularized tracheal transplantation].

作者信息

Delaere P

机构信息

K.U.L., UZ Leuven.

出版信息

Bull Mem Acad R Med Belg. 2011;166(10-12):377-9; discussion 380.

Abstract

Reconstruction of long-segment tracheal defects requires a vascularized allograft. We report successful tracheal allotransplantation after indirect revascularization of the graft in a heterotopic position. Immunosuppressive therapy was administered before the operation, and the allograft was wrapped in the recipient's forearm fascia. Once revascularization was achieved, the mucosal lining was replaced progressively with buccal mucosa from the recipient. At four months, the tracheal chimera was fully lined with mucosa, which consisted of respiratory epithelium from the donor and buccal mucosa from the recipient. After withdrawal of immunosuppressive therapy, the tracheal allograft was moved to its correct anatomical position with an intact blood supply. No treatment-limiting adverse effects occurred.

摘要

长节段气管缺损的重建需要带血管的同种异体移植物。我们报告了在将移植物置于异位进行间接血管化后成功进行气管同种异体移植的案例。术前给予免疫抑制治疗,并将同种异体移植物包裹在受体的前臂筋膜中。一旦实现血管化,就逐渐用受体的颊黏膜替换黏膜内衬。四个月时,气管嵌合体完全被黏膜覆盖,该黏膜由供体的呼吸道上皮和受体的颊黏膜组成。在停用免疫抑制治疗后,气管同种异体移植物被转移到其正确的解剖位置,血供完整。未出现限制治疗的不良反应。

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