陆地蜗牛中胆钙化醇的代谢
Metabolism of cholecalciferol in land snails.
作者信息
Weiner S, Noff D, Meyer M S, Weisman Y, Edelstein S
出版信息
Biochem J. 1979 Oct 15;184(1):157-61. doi: 10.1042/bj1840157.
Abstract
- Radioactively labelled cholecalciferol was injected into the land snails Levantina hiersolyma and Theba pisana. Three metabolites (C, D and E), more polar than cholecalciferol, were found. 2. Metabolite C was found to be identical with 25-hydroxycholecalciferol. On injection of 25-hydroxy[26,27-3H]cholecalciferol, metabolite E was predominantly formed. Metabolite D was predominantly formed from cholecalciferol. Metabolites D and E differ from any known cholecalciferol metabolites. 3. The intestine was found to be the tissue capable of carrying out the transformation of 25-hydroxycholecalciferol into metabolite E. 4. 25-Hydroxycholecalciferol and metabolite E were localized in the digestive gland of the snail, the tissue responsible for the absorption of Ca2+ and its storage. Metabolite D was not localized in any specific tissue.
摘要
- 将放射性标记的胆钙化醇注射到陆地蜗牛黎凡特蜗牛（Levantina hiersolyma）和地中海蜗牛（Theba pisana）体内。发现了三种比胆钙化醇极性更强的代谢产物（C、D和E）。2. 发现代谢产物C与25-羟基胆钙化醇相同。注射25-羟基[26,27-³H]胆钙化醇后，主要形成代谢产物E。代谢产物D主要由胆钙化醇形成。代谢产物D和E与任何已知的胆钙化醇代谢产物都不同。3. 发现肠道是能够将25-羟基胆钙化醇转化为代谢产物E的组织。4. 25-羟基胆钙化醇和代谢产物E定位于蜗牛的消化腺，该组织负责Ca²⁺的吸收及其储存。代谢产物D未定位于任何特定组织。
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