Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
J Thromb Haemost. 2012 Dec;10(12):2519-25. doi: 10.1111/jth.12034.
Coffee consumption is associated with a lower risk of venous thrombosis, but the role of confounding and the pathophysiology behind these findings are unclear.
To assess the role of hemostatic factors in the relationship between coffee consumption and venous thrombosis.
From a large case-control study, 1803 patients with a first venous thrombosis and 1803 partner controls were included. With conditional logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) for venous thrombosis were calculated for coffee consumption vs. no coffee consumption. In addition, mean differences in hemostatic factor levels between these groups were calculated in the controls.
Coffee consumption yielded a 30% lower risk of venous thrombosis than no coffee consumption (OR 0.7, 95% CI 0.5-0.9). Adjustment for several putative confounders (age, sex, body mass index, smoking, hormonal factors, statin, aspirin, alcohol, malignancy, and chronic disease) yielded an OR of 0.8 (95% CI 0.6-1.1). Results were similar for provoked and unprovoked events, and for deep vein thrombosis and pulmonary embolism. In controls, von Willebrand factor levels were 11 (3-19) IU dL(-1) lower and factor (F) VIII levels were 11 (1-21) IU dL(-1) lower in coffee consumers than in non-consumers. After adjustment of the risk estimates for these hemostatic factors, the inverse association between coffee consumption and venous thrombosis diminished (OR 1.0, 95% CI 0.7-1.4). There was no association between coffee consumption and anticoagulant proteins, fibrinogen levels, or fibrinolytic markers.
Coffee consumption is associated with a lower risk of venous thrombosis, which seems to be mediated through von Willebrand factor and FVIII.
咖啡的摄入与静脉血栓形成的风险降低有关，但混杂因素的作用和这些发现背后的病理生理学机制尚不清楚。
评估止血因子在咖啡摄入与静脉血栓形成之间关系中的作用。
从一项大型病例对照研究中，纳入了 1803 例首发静脉血栓形成患者和 1803 名配对对照者。采用条件 logistic 回归，计算了与不喝咖啡相比，喝咖啡与静脉血栓形成的比值比（OR）及其 95%置信区间（CI）。此外，在对照组中计算了这些组间止血因子水平的均值差异。
与不喝咖啡相比，咖啡摄入使静脉血栓形成的风险降低了 30%（OR 0.7，95%CI 0.5-0.9）。调整几个可能的混杂因素（年龄、性别、体重指数、吸烟、激素因素、他汀类药物、阿司匹林、酒精、恶性肿瘤和慢性病）后，OR 为 0.8（95%CI 0.6-1.1）。结果对于诱发和非诱发事件以及深静脉血栓形成和肺栓塞均相似。在对照组中，与非咖啡饮用者相比，咖啡饮用者的血管性血友病因子（von Willebrand factor）水平低 11（3-19）IU dL(-1)，因子 VIII 水平低 11（1-21）IU dL(-1)。在调整这些止血因子的风险估计值后，咖啡摄入与静脉血栓形成之间的负相关减弱（OR 1.0，95%CI 0.7-1.4）。咖啡摄入与抗凝蛋白、纤维蛋白原水平或纤维蛋白溶解标志物之间无关联。
咖啡的摄入与静脉血栓形成的风险降低有关，这似乎是通过血管性血友病因子和因子 VIII 介导的。
