孕酮21-羟基甾体代谢物的一种新型色谱拆分方法。
A novel chromatographic resolution of 21-hydroxysteroid metabolites of progesterone.
作者信息
Senciall I R, Roberts R, Rahal S
机构信息
Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
出版信息
J Steroid Biochem. 1990 Jan;35(1):151-4. doi: 10.1016/0022-4731(90)90161-k.
21-Hydroxysteroid metabolites of both progesterone and deoxycorticosterone are excreted in rabbit urine and are eluted from an alumina adsorption column after 21-deoxysteroids. The separation is independent of polarity and dependent on the interaction of the 21-hydroxyl function with the adsorbent. The group separation of these steroids allowed further analysis by high performance liquid chromatography and revealed different proportions of metabolites. This is the first report of the excretion of 21-hydroxysteroid metabolites of progesterone in rabbit urine.
孕酮和脱氧皮质酮的21-羟基类固醇代谢物在兔尿中排泄，并在21-脱氧类固醇之后从氧化铝吸附柱上洗脱下来。这种分离与极性无关，而是取决于21-羟基官能团与吸附剂的相互作用。这些类固醇的分组分离使得通过高效液相色谱法进行进一步分析成为可能，并揭示了不同比例的代谢物。这是关于孕酮的21-羟基类固醇代谢物在兔尿中排泄的首次报道。
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