Biomaterials Development and Control Center, Federal University of Pelotas, Pelotas, RS, Brazil.
Dent Mater. 2012 Dec;28(12):1199-206. doi: 10.1016/j.dental.2012.08.009. Epub 2012 Oct 18.
The purpose of this study was to evaluate the reactivity and polymerization kinetics behavior of a model dental adhesive resin with water-soluble initiator systems.
A monomer blend based on Bis-GMA, TEGDMA and HEMA was used as a model dental adhesive resin, which was polymerized using a thioxanthone type (QTX) as a photoinitiator. Binary and ternary photoinitiator systems were formulated using 1mol% of each initiator. The co-initiators used in this study were ethyl 4-dimethylaminobenzoate (EDAB), diphenyliodonium hexafluorophosphate (DPIHFP), 1,3-diethyl-2-thiobarbituric acid (BARB), p-toluenesulfinic acid and sodium salt hydrate (SULF). Absorption spectra of the initiators were measured using a UV-Vis spectrophotometer, and the photon absorption energy (PAE) was calculated. The binary system camphorquinone (CQ)/amine was used as a reference group (control). Twelve groups were tested in triplicate. Fourier-transform infrared spectroscopy (FTIR) was used to investigate the polymerization reaction during the photoactivation period to obtain the degree of conversion (DC) and maximum polymerization rate (R(p)(max)) profile of the model resin.
In the analyzed absorption profiles, the absorption spectrum of QTX is almost entirely localized in the UV region, whereas that of CQ is in the visible range. With respect to binary systems, CQ+EDAB exhibited higher DC and R(p)(max) values. In formulations that contained ternary initiator systems, the group CQ+QTX+EDAB was the only one of the investigated experimental groups that exhibited an R(p)(max) value greater than that of CQ+EDAB. The groups QTX+EDAB+DPIHFP and QTX+DPIHFP+SULF exhibited values similar to those of CQ+EDAB with respect to the final DC; however, they also exhibited lower reactivity.
Water-soluble initiator systems should be considered as alternatives to the widely used CQ/amine system in dentin adhesive formulations.
本研究旨在评估一种含有水溶性引发剂体系的模型牙科黏附树脂的反应性和聚合动力学行为。
采用 Bis-GMA、TEGDMA 和 HEMA 单体混合物作为模型牙科黏附树脂，以噻吨酮型（QTX）作为光引发剂进行聚合。采用二种和三种光引发剂体系，每种引发剂的用量为 1mol%。本研究中使用的共引发剂为乙基 4-二甲氨基苯甲酸酯（EDAB）、二苯基碘𬭩六氟磷酸盐（DPIHFP）、1,3-二乙基-2-硫代巴比妥酸（BARB）、对甲苯亚磺酸及钠盐水合物（SULF）。用紫外-可见分光光度计测量引发剂的吸收光谱，并计算光子吸收能（PAE）。以樟脑醌（CQ）/胺二元体系作为参比组（对照）。每组实验重复三次，共 12 组。傅里叶变换红外光谱（FTIR）用于研究光激活期间的聚合反应，以获得模型树脂的转化率（DC）和最大聚合速率（R(p)(max)）曲线。
在分析的吸收曲线中，QTX 的吸收光谱几乎完全局限于紫外区域，而 CQ 的吸收光谱则在可见范围内。对于二元体系，CQ+EDAB 表现出更高的 DC 和 R(p)(max) 值。在含有三元引发剂体系的配方中，仅 CQ+QTX+EDAB 组在研究的实验组中表现出大于 CQ+EDAB 的 R(p)(max) 值。CQ+QTX+EDAB+DPIHFP 和 QTX+EDAB+DPIHFP+SULF 组在最终 DC 方面与 CQ+EDAB 相似，但反应性较低。
在牙本质黏附配方中，水溶性引发剂体系应被视为广泛使用的 CQ/胺体系的替代品。
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