Division of Urology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
J Urol. 2012 Dec;188(6):2246-51. doi: 10.1016/j.juro.2012.08.040. Epub 2012 Oct 22.
Residual fragments following ureteroscopy for calculi may contribute to stone growth, symptoms or additional interventions. We reviewed our experience with ureteroscopy for calculus disease to define the incidence and establish factors predictive of residual fragments.
Records associated with 667 consecutive ureteroscopic lithotripsy procedures for upper urinary calculi were reviewed. In 265 procedures (40%) computerized tomography was done between 30 and 90 days postoperatively. They comprised the study group. Residual fragments were defined as any residual ipsilateral stone greater than 2 mm.
Included in the study were 121 men and 127 women with a mean age of 47 years. Mean target stone diameter was 7.6 mm. The stone location was the kidney in 30% of cases, ureter in 50%, and kidney and ureter in 20%. Residual fragments were detected on computerized tomography after 101 of 265 procedures (38%). Pretreatment stone size was associated with residual fragments at a rate of 24%, 40% and 58% for stones 5 or less, 6 to 10 and greater than 10 mm, respectively (p <0.001). Additionally, stone location in the kidney (p <0.001) or the kidney and ureter (p = 0.044), multiple calculi (p = 0.003), longer operative time (p = 0.008) and exclusive use of flexible ureteroscopy (p = 0.029) were associated with residual fragments. In a multivariate model only pretreatment stone diameter greater than 5 mm was independently associated with residual fragments after ureteroscopy (diameter 6 to 10 and greater than 10 mm OR 2.03, p = 0.03 and OR 3.74, p = 0.003, respectively).
Of patients who underwent ureteroscopic lithotripsy for calculi 38% had residual fragments by computerized tomography criteria, including more than 50% with stones 1 cm or greater. Such data may guide expectations regarding the success of ureteroscopy in attaining stone-free status.
输尿管镜碎石术后残留结石碎片可能导致结石生长、症状或进一步干预。我们回顾了输尿管镜碎石术治疗上尿路结石的经验,以确定残留结石碎片的发生率,并确定其预测因素。
回顾 667 例连续接受输尿管镜碎石术治疗上尿路结石患者的病历资料。265 例(40%)患者在术后 30-90 天内行 CT 检查,将其作为研究组。残留结石碎片定义为同侧大于 2mm 的任何残留结石。
研究共纳入 121 例男性和 127 例女性患者,平均年龄 47 岁。平均目标结石直径为 7.6mm。结石位置在肾脏占 30%,输尿管占 50%,肾脏和输尿管均占 20%。265 例患者中有 101 例(38%)在 CT 检查中发现残留结石碎片。术前结石大小与残留结石碎片相关,结石大小为 5mm 及以下、6-10mm 和大于 10mm 时的残留率分别为 24%、40%和 58%(p<0.001)。此外,肾结石(p<0.001)或肾结石合并输尿管结石(p=0.044)、多发结石(p=0.003)、手术时间较长(p=0.008)和单纯使用软性输尿管镜(p=0.029)与残留结石碎片有关。多变量模型分析仅提示术前结石直径大于 5mm 是输尿管镜碎石术后残留结石碎片的独立预测因素(直径为 6-10mm 和大于 10mm 时 OR 分别为 2.03,p=0.03 和 OR 为 3.74,p=0.003)。
在接受输尿管镜碎石术治疗的患者中,有 38%的患者根据 CT 标准存在残留结石碎片,其中大于 50%的患者结石直径为 1cm 或以上。此类数据可能有助于预测输尿管镜碎石术达到无石状态的成功率。