Department of Pathobiology and Veterinary Sciences, University of Connecticut, Storrs, USA.
Vaccine. 2012 Nov 26;30(50):7153-6. doi: 10.1016/j.vaccine.2012.10.013. Epub 2012 Oct 18.
Hydropericardium syndrome (HPS) is a disease of poultry that is caused by fowl adenovirus-4. Inactivated liver homogenate from diseased birds is still the choice of vaccine in some countries which disseminates numerous pathogens along with inactivated virus. Moreover incomplete attenuation or inactivation, reversion to virulence and the oncogenic potential/genetic instability of the adenoviruses have prevented their use in routine vaccines. To address this problem an effort is made to develop a subunit vaccine. For this purpose penton base protein of HPS virus was expressed in Escherichia coli and used as subunit vaccine in broilers. Immunogenicity of the recombinant penton base protein and challenge protection test against pathogenic virus demonstrated the ability of recombinant penton base protein to confer (90%) protection. Results suggest that the recombinant penton base protein is a candidate for subunit vaccine against HPS.
水禽疱疹病毒病（HPS）是一种由禽腺病毒 4 型引起的禽类疾病。在一些国家，病禽的灭活肝匀浆仍然是疫苗的选择，这种疫苗会传播大量病原体以及灭活病毒。此外，腺病毒不完全减毒或失活、毒力回复以及致癌潜力/遗传不稳定性，阻止了它们在常规疫苗中的应用。为了解决这个问题，人们努力开发亚单位疫苗。为此，HPS 病毒的五邻体基底蛋白在大肠杆菌中表达，并作为亚单位疫苗用于肉鸡。重组五邻体基底蛋白的免疫原性和对致病性病毒的攻毒保护试验表明，重组五邻体基底蛋白能够提供（90%）保护。结果表明，重组五邻体基底蛋白是预防 HPS 的亚单位疫苗的候选物。
