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本文引用的文献

1
Antioxidants in kidney diseases: the impact of bardoxolone methyl.肾脏疾病中的抗氧化剂：巴多昔芬甲基的影响
Int J Nephrol. 2012;2012:321714. doi: 10.1155/2012/321714. Epub 2012 Jun 4.
2
Lipoxin A4 attenuates adipose inflammation.脂氧素 A4 可减轻脂肪组织炎症。
FASEB J. 2012 Oct;26(10):4287-94. doi: 10.1096/fj.12-208249. Epub 2012 Jun 14.
3
Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation.消退素E1和D1通过抑制局部成纤维细胞增殖来抑制梗阻性肾病中的间质纤维化。
J Pathol. 2012 Dec;228(4):506-19. doi: 10.1002/path.4050. Epub 2012 Nov 6.
4
Update on potential drugs for the treatment of diabetic kidney disease.治疗糖尿病肾病的潜在药物研究进展。
Clin Ther. 2012 Jun;34(6):1237-46. doi: 10.1016/j.clinthera.2012.04.026. Epub 2012 May 11.
5
Aspirin-triggered lipoxin A₄ attenuates lipopolysaccharide-induced intracellular ROS in BV2 microglia cells by inhibiting the function of NADPH oxidase.阿司匹林诱导的脂氧素 A₄ 通过抑制 NADPH 氧化酶的功能来减轻 LPS 诱导的 BV2 小胶质细胞内 ROS 的产生。
Neurochem Res. 2012 Aug;37(8):1690-6. doi: 10.1007/s11064-012-0776-3. Epub 2012 May 3.
6
Interleukin-1 receptor antagonist: a new therapy for type 2 diabetes mellitus.白细胞介素-1 受体拮抗剂：2 型糖尿病的一种新疗法。
J Pharm Sci. 2012 May;101(5):1647-58. doi: 10.1002/jps.23057. Epub 2012 Jan 23.
7
Glycated haemoglobin--a marker and predictor of cardiovascular disease.糖化血红蛋白——心血管疾病的一个标志物及预测指标。
J Pak Med Assoc. 2011 Jul;61(7):690-5.
8
Diabetes: bardoxolone improves kidney function in type 2 diabetes.糖尿病：巴多昔芬可改善2型糖尿病患者的肾功能。
Nat Rev Nephrol. 2011 Aug 23;7(10):552-3. doi: 10.1038/nrneph.2011.114.
9
Bardoxolone methyl and kidney function in CKD with type 2 diabetes.巴多索隆甲和 2 型糖尿病 CKD 患者的肾功能。
N Engl J Med. 2011 Jul 28;365(4):327-36. doi: 10.1056/NEJMoa1105351. Epub 2011 Jun 24.
10
Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.脂氧素 A4 和苯并脂氧素 A4 可减轻实验性肾纤维化。
FASEB J. 2011 Sep;25(9):2967-79. doi: 10.1096/fj.11-185017. Epub 2011 May 31.

解决炎症：在 2 型糖尿病及其相关肾脏并发症中，促解决脂质的治疗潜力。

Resolution of inflammation: therapeutic potential of pro-resolving lipids in type 2 diabetes mellitus and associated renal complications.

机构信息

UCD Diabetes Research Centre, UCD Conway Institute, School of Medicine and Medical Sciences, University College Dublin Dublin, Ireland.

出版信息

Front Immunol. 2012 Oct 18;3:318. doi: 10.3389/fimmu.2012.00318. eCollection 2012.

DOI:10.3389/fimmu.2012.00318
PMID:23087692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3474937/
Abstract

The role of inflammation in the pathogenesis of type 2 diabetes mellitus (T2DM) and its associated complications is increasingly recognized. The resolution of inflammation is actively regulated by endogenously produced lipid mediators such as lipoxins, resolvins, protectins, and maresins. Here we review the potential role of these lipid mediators in diabetes-associated pathologies, specifically focusing on adipose inflammation and diabetic kidney disease, i.e., diabetic nephropathy (DN). DN is one of the major complications of T2DM and we propose that pro-resolving lipid mediators may have therapeutic potential in this context. Adipose inflammation is also an important component of T2DM-associated insulin resistance and altered adipokine secretion. Promoting the resolution of adipose inflammation would therefore likely be a beneficial therapeutic approach in T2DM.

摘要

炎症在 2 型糖尿病（T2DM）及其相关并发症的发病机制中的作用正日益受到重视。内源性产生的脂质介质如脂氧素、消退素、保护素和maresin 可积极调节炎症的消退。在这里，我们综述了这些脂质介质在与糖尿病相关的病理中的潜在作用，特别是在脂肪炎症和糖尿病肾病（DN），即糖尿病肾病方面。DN 是 T2DM 的主要并发症之一，我们提出，促解决的脂质介质在这种情况下可能具有治疗潜力。脂肪炎症也是 T2DM 相关胰岛素抵抗和改变的脂肪因子分泌的一个重要组成部分。因此，促进脂肪炎症的消退可能是 T2DM 的一种有益的治疗方法。