Cavaillon J M
Unité d'Immuno-Allergie, Institut Pasteur, Paris, France.
Pathol Biol (Paris). 1990 Jan;38(1):36-42.
Interleukins (IL) are a heterogeneous class of cytokines involved in activation of T lymphocytes (IL-1, 2, 4, 6 and 7), B lymphocytes (IL-1, 2, 4, 5, 6 and 7), and macrophages (IL-1 and 4), and hematopoiesis (IL-1, 2, 3, 4, 5, 6 and 7), acting either by themselves, or as co-stimulator factors. Interleukin-1 (IL-1 alpha and IL-1 beta) is induced by different signals including microbial products; it mediates various events occurring during inflammation (e.g. fever, osteolysis, leucopenia, hypotension, hyperalgia, etc...). Such mechanisms are often the consequences of the induction by IL-1 of lipid mediators (e.g. prostaglandins, platelet activating factor, etc). IL-1 often acts synergistically with Tumor Necrosis Factor during the pro-inflammatory process. IL-1 as well as microbial products induces the production of interleukin-6 and interleukin-8. IL-6 also plays a role in inflammation, mainly as an inducer of acute phase proteins synthesis by hepatocytes. IL-8 has chemotactic and activating properties for neutrophils.
白细胞介素（IL）是一类异质性细胞因子，参与T淋巴细胞（IL-1、2、4、6和7）、B淋巴细胞（IL-1、2、4、5、6和7）及巨噬细胞（IL-1和4）的激活，以及造血作用（IL-1、2、3、4、5、6和7），它们可单独发挥作用，也可作为共刺激因子起作用。白细胞介素-1（IL-1α和IL-1β）由包括微生物产物在内的不同信号诱导产生；它介导炎症过程中发生的各种事件（如发热、骨质溶解、白细胞减少、低血压、痛觉过敏等）。这些机制通常是IL-1诱导脂质介质（如前列腺素、血小板活化因子等）产生的结果。在促炎过程中，IL-1常与肿瘤坏死因子协同发挥作用。IL-1以及微生物产物可诱导白细胞介素-6和白细胞介素-8的产生。IL-6也在炎症中起作用，主要作为肝细胞合成急性期蛋白的诱导剂。IL-8对中性粒细胞具有趋化和激活特性。
