Lozach Pierre-Yves, Helenius Ari
Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
Duodecim. 2012;128(18):1929-35.
In Ralf Pettersson, we have lost an influential and internationally recognized investigator with a significant impact in the field of animal virology. The Bunyaviridae constitute the viral family that he studied the most. These are relatively simple enveloped viruses with a tri-segmented negative-sense single-stranded RNA genome. With few exceptions, bunyaviruses are transmitted by arthropod vectors and are introduced into the skin of hosts via bites of infected arthropods. Dermal dendritic cells (DCs) are among the first cells to encounter incoming viruses. In this short review, we will discuss how arthropod-borne viruses exploit DCs to spread throughout the body of the human host. The mechanism depends on interactions with DC-SIGN, a C-type lectin abundantly expressed on DCs.
我们失去了一位在动物病毒学领域具有重大影响力且国际知名的研究者拉尔夫·佩特松。布尼亚病毒科是他研究最多的病毒家族。这些是相对简单的包膜病毒，具有三段负链单链RNA基因组。除少数例外，布尼亚病毒通过节肢动物媒介传播，并通过受感染节肢动物的叮咬进入宿主皮肤。皮肤树突状细胞（DCs）是最早接触传入病毒的细胞之一。在这篇简短的综述中，我们将讨论节肢动物传播的病毒如何利用DCs在人类宿主体内传播。其机制取决于与DC-SIGN的相互作用，DC-SIGN是一种在DCs上大量表达的C型凝集素。
