Moh In Ho, Kim Jin Bae, Shin Su Rin, Jung Sung Won, Park Sang Hoon, Kim Jeong Won, Shin Mi Kyung, Lee Myung Seok
Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2012 Oct;60(4):258-61. doi: 10.4166/kjg.2012.60.4.258.
The term inflammatory pseudotumor (IPT) has been used to describe inflammatory and fibrosing tumoral processes of an undetermined cause that may involve a variety of organ system. IgG4-related disease is a newly recognized fibroinflammatory condition characterized by IgG4-producing plasma cell expansion in affected organs and, often but not always, elevated serum IgG4 concentrations. IgG4-related IPTs, a subtype of IPT, are characterized by dense infiltration of IgG4-positive plasma cells and stromal fibrosis. The association between inflammatory pseudotumor and IgG4 was first reported with a regard to sclerosing pancreatitis. Despite there are many reports on intraperitoneal IPTs including both cellular and lymphoplasmacytic type, only a few cases have been confirmed to be IgG4-related. We experienced a case of intraperitoneal IgG4-related inflammatory pseudotumor in an 83-year-old woman presenting with epigastric pain and malaise. Surgical specimens revealed an IgG4-related inflammatory pseudotumor.
炎性假瘤（IPT）这一术语已被用于描述病因不明的炎性和纤维性肿瘤性病变，其可能累及多种器官系统。IgG4相关疾病是一种新认识的纤维炎性疾病，其特征为受累器官中产生IgG4的浆细胞增多，且血清IgG4浓度常（但不总是）升高。IgG4相关IPT是IPT的一种亚型，其特征为IgG4阳性浆细胞的密集浸润和间质纤维化。炎性假瘤与IgG4之间的关联最早是在硬化性胰腺炎方面被报道的。尽管有许多关于腹腔内IPT的报道，包括细胞型和淋巴浆细胞型，但仅有少数病例被证实与IgG4相关。我们遇到一例83岁女性腹腔内IgG4相关炎性假瘤，患者表现为上腹部疼痛和不适。手术标本显示为IgG4相关炎性假瘤。
