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Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters.

作者信息

Brauch Hiltrud, Schroth Werner, Goetz Matthew P, Mürdter Thomas E, Winter Stefan, Ingle James N, Schwab Matthias, Eichelbaum Michel

机构信息

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

出版信息

J Clin Oncol. 2013 Jan 10;31(2):176-80. doi: 10.1200/JCO.2012.44.6625. Epub 2012 Oct 22.

DOI:10.1200/JCO.2012.44.6625
PMID:23091108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3731938/
Abstract
摘要

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Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters.他莫昔芬在绝经后乳腺癌中的应用：细胞色素P450 2D6起重要作用。
J Clin Oncol. 2013 Jan 10;31(2):176-80. doi: 10.1200/JCO.2012.44.6625. Epub 2012 Oct 22.
2
CYP2D6 genotype should not be used for deciding about tamoxifen therapy in postmenopausal breast cancer.细胞色素P450 2D6（CYP2D6）基因分型不应用于决定绝经后乳腺癌患者的他莫昔芬治疗方案。
J Clin Oncol. 2013 Jul 20;31(21):2753-5. doi: 10.1200/JCO.2013.49.4278. Epub 2013 Jun 17.
3
CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.CYP2D6 基因型与内分泌治疗反应性乳腺癌绝经后妇女的关系：乳腺国际研究组 1-98 试验。
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Prediction of tamoxifen outcome by genetic variation of CYP2D6 in post-menopausal women with early breast cancer.CYP2D6基因变异对绝经后早期乳腺癌女性他莫昔芬治疗结局的预测作用
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CYP2D6 genotyping and tamoxifen in the treatment of post-menopausal breast cancer - a reply.CYP2D6基因分型与他莫昔芬在绝经后乳腺癌治疗中的应用——答复
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Why should results from metastatic trials no longer matter for early-stage disease?为什么转移性试验的结果对早期疾病不再重要？
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Reply to A.-S. Dieudonné et al and J.M. Rae et al.对A.-S.迪厄多内等人以及J.M.雷伊等人的回复
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本文引用的文献

1
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.关于：绝经后内分泌反应性乳腺癌患者的CYP2D6基因分型与他莫昔芬反应：国际乳腺癌研究组1-98试验
J Natl Cancer Inst. 2012 Aug 22;104(16):1264; author reply 1266-8. doi: 10.1093/jnci/djs304. Epub 2012 Jul 31.
2
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial and Re: CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients.回复：绝经后内分泌反应性乳腺癌患者的CYP2D6基因分型与他莫昔芬反应：国际乳腺癌研究组1-98试验 以及 回复：CYP2D6和UGT2B7基因分型与他莫昔芬治疗的乳腺癌患者复发风险
J Natl Cancer Inst. 2012 Aug 22;104(16):1263-4; author reply 1266-8. doi: 10.1093/jnci/djs312. Epub 2012 Jul 31.
3
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.回复：绝经后内分泌反应性乳腺癌患者的CYP2D6基因分型与他莫昔芬反应：国际乳腺癌研究组1-98试验
J Natl Cancer Inst. 2012 Aug 22;104(16):1265-6; author reply 1266-8. doi: 10.1093/jnci/djs305. Epub 2012 Jul 31.
4
CYP2D6 genotype as a marker for benefit of adjuvant tamoxifen in postmenopausal women: lessons learned.细胞色素P450 2D6基因分型作为绝经后女性辅助性他莫昔芬获益的标志物：经验教训
J Natl Cancer Inst. 2012 Mar 21;104(6):427-8. doi: 10.1093/jnci/djs139. Epub 2012 Mar 6.
5
CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.CYP2D6 基因型与内分泌治疗反应性乳腺癌绝经后妇女的关系：乳腺国际研究组 1-98 试验。
J Natl Cancer Inst. 2012 Mar 21;104(6):441-51. doi: 10.1093/jnci/djs125. Epub 2012 Mar 6.
6
CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients.CYP2D6 和 UGT2B7 基因型与他莫昔芬治疗的乳腺癌患者复发风险。
J Natl Cancer Inst. 2012 Mar 21;104(6):452-60. doi: 10.1093/jnci/djs126. Epub 2012 Mar 6.
7
Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: effect on active metabolite isomers and the antiestrogenic activity score.根据 CYP2D6 基因型和依西美坦水平增加乳腺癌患者的他莫昔芬剂量：对活性代谢物异构体和抗雌激素活性评分的影响。
Clin Pharmacol Ther. 2011 Oct;90(4):605-11. doi: 10.1038/clpt.2011.153. Epub 2011 Sep 7.
8
Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study.基因指导的他莫昔芬剂量增加了 CYP2D6 代谢降低的女性中活性代谢物的暴露：一项多中心研究。
J Clin Oncol. 2011 Aug 20;29(24):3232-9. doi: 10.1200/JCO.2010.31.4427. Epub 2011 Jul 18.
9
Personalized tamoxifen: what is the best way forward?个性化他莫昔芬治疗：最佳前进方向是什么？
J Clin Oncol. 2011 Aug 20;29(24):3206-8. doi: 10.1200/JCO.2011.36.3895. Epub 2011 Jul 18.
10
Preemptive pharmacogenetic testing: insufficient data equal unsatisfactory guidance.预防性药物遗传学检测：数据不足导致指导意见不尽人意。
Ann Intern Med. 2011 Jun 21;154(12):842-4. doi: 10.7326/0003-4819-154-12-201106210-00016.