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颅面综合征的牙科治疗方法：发育领域如何能为我们提供一种理解发病机制的新途径？

Dental approach to craniofacial syndromes: how can developmental fields show us a new way to understand pathogenesis?

作者信息

Kjær Inger

机构信息

Department of Orthodontics, Institute of Odontology, Faculty of Health Sciences, University of Copenhagen, 20 Nørre Allé, DK-2200 Copenhagen, Denmark.

出版信息

Int J Dent. 2012;2012:145749. doi: 10.1155/2012/145749. Epub 2012 Oct 2.

DOI:10.1155/2012/145749
PMID:23091490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3467949/
Abstract

The paper consists of three parts. Part 1: Definition of Syndromes. Focus is given to craniofacial syndromes in which abnormal traits in the dentition are associated symptoms. In the last decade, research has concentrated on phenotype, genotype, growth, development, function, and treatment. Part 2: Syndromes before Birth. How can the initial malformation sites in these syndromes be studied and what can we learn from it? In this section, deviations observed in syndromes prenatally will be highlighted and compared to the normal human embryological craniofacial development. Specific focus will be given to developmental fields studied on animal tissue and transferred to human cranial development. Part 3: Developmental Fields Affected in Two Craniofacial Syndromes. Analysis of primary and permanent dentitions can determine whether a syndrome affects a single craniofacial field or several fields. This distinction is essential for insight into craniofacial syndromes. The dentition, thus, becomes central in diagnostics and evaluation of the pathogenesis. Developmental fields can explore and advance the concept of dental approaches to craniofacial syndromes. Discussion. As deviations in teeth persist and do not reorganize during growth and development, the dentition is considered useful for distinguishing between syndrome pathogenesis manifested in a single developmental field and in several fields.

摘要

本文由三部分组成。第一部分：综合征的定义。重点关注牙列异常特征为相关症状的颅面综合征。在过去十年中，研究集中在表型、基因型、生长、发育、功能和治疗方面。第二部分：出生前的综合征。如何研究这些综合征的初始畸形部位，我们能从中了解到什么？在本节中，将突出产前综合征中观察到的偏差，并与正常人类胚胎颅面发育进行比较。将特别关注在动物组织上研究并应用于人类颅骨发育的发育领域。第三部分：两种颅面综合征中受影响的发育领域。对乳牙列和恒牙列的分析可以确定一种综合征是否影响单个颅面领域或多个领域。这种区分对于深入了解颅面综合征至关重要。因此，牙列在颅面综合征的诊断和发病机制评估中变得至关重要。发育领域可以探索并推进针对颅面综合征的牙科治疗方法的概念。讨论。由于牙齿的偏差在生长发育过程中持续存在且不会重新组织，因此牙列被认为有助于区分在单个发育领域和多个领域表现出的综合征发病机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/fbf4978fc86a/IJD2012-145749.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/fa823ef146ea/IJD2012-145749.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/9865a4d254bf/IJD2012-145749.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/354d33a3b63a/IJD2012-145749.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/79a5e1efb106/IJD2012-145749.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/4c23ae2e5dae/IJD2012-145749.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/51a03f726abb/IJD2012-145749.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/f001056455ab/IJD2012-145749.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/4f4fe95be501/IJD2012-145749.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/52942a1a68e0/IJD2012-145749.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/db00ff123bae/IJD2012-145749.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/fbf4978fc86a/IJD2012-145749.011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/fa823ef146ea/IJD2012-145749.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/9865a4d254bf/IJD2012-145749.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/354d33a3b63a/IJD2012-145749.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/79a5e1efb106/IJD2012-145749.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/4c23ae2e5dae/IJD2012-145749.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/51a03f726abb/IJD2012-145749.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/f001056455ab/IJD2012-145749.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/4f4fe95be501/IJD2012-145749.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/52942a1a68e0/IJD2012-145749.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/db00ff123bae/IJD2012-145749.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e95/3467949/fbf4978fc86a/IJD2012-145749.011.jpg

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