Institute of Cardiovascular Research Center, Pusan National University Yangsan Hospital, Yangsan, Korea.
Korean Circ J. 2012 Sep;42(9):600-5. doi: 10.4070/kcj.2012.42.9.600. Epub 2012 Sep 27.
We investigated whether 1 hour reperfusion is enough to assess cardiodynamics and infarct size in both regional ischemia (RI) and global ischemia (GI) in isolated rat heart models.
Hearts were randomly assigned to one of the following groups (each n=14): 1) Sham hearts for 1 hour; 2) Sham hearts for 2 hours; 3) 30 minutes RI followed by 1 hour reperfusion; 4) 30 minutes of RI followed by 2 hours reperfusion; 5) 30 minutes GI followed by 1 hour reperfusion; and 6) 30 minutes GI followed by 2 hours reperfusion.
There were no significant differences in infarct size between 1 hour and 2 hours reperfusion in both RI and GI. Left ventricular developed pressure was significantly decreased at both 1 hour and 2 hours reperfusion in groups of RI and GI compared to baseline (p<0.01). Rate-pressure product and +dP/dt(max) also significantly decreased compared to baseline level at both 1 hour and 2 hours reperfusion in groups of RI and GI (p<0.05).
There was no significant difference in infarct size between 1 hour and 2 hours reperfusion in groups of RI and GI. Cardiodynamic variables measured at 1 hour and 2 hours reperfusion significantly decreased compared to baseline level. Our data suggests that reperfusion of 1 hour is sufficient to assess cardiodynamics in both regional and global ischemic isolated hearts model.
我们研究了在局部缺血（RI）和整体缺血（GI）的离体鼠心模型中，1 小时再灌注是否足以评估心动力学和梗死面积。
心脏随机分为以下组之一（每组 n=14）：1） Sham 心脏 1 小时；2）Sham 心脏 2 小时；3）30 分钟 RI 后 1 小时再灌注；4）30 分钟 RI 后 2 小时再灌注；5）30 分钟 GI 后 1 小时再灌注；和 6）30 分钟 GI 后 2 小时再灌注。
在 RI 和 GI 中，1 小时和 2 小时再灌注之间的梗死面积无显著差异。与基线相比，RI 和 GI 组在 1 小时和 2 小时再灌注时左心室发展压均显著降低（p<0.01）。与 RI 和 GI 组的基线水平相比，在 1 小时和 2 小时再灌注时，率-压乘积和+dP/dt(max)也显著降低（p<0.05）。
在 RI 和 GI 组中，1 小时和 2 小时再灌注之间的梗死面积无显著差异。在 1 小时和 2 小时再灌注时，与基线水平相比，心动力学变量显著降低。我们的数据表明，1 小时的再灌注足以评估局部和整体缺血离体心脏模型的心动力学。
