氧化双（三正丁基锡）（TBTO）对小鼠的胚胎毒性评估
Embryotoxic evaluation of bis(tri-n-butyltin)oxide (TBTO) in mice.
作者信息
Baroncelli S, Karrer D, Turillazzi P G
机构信息
Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Toxicol Lett. 1990 Feb;50(2-3):257-62. doi: 10.1016/0378-4274(90)90018-h.
PMID:2309244
Abstract
Pregnant mice were treated on days 6-15 of gestation with 5, 20 and 40 mg/kg/d bis(tri-n-butyltin)oxide (TBTO), and sacrificed on gestational day 17. At the highest dose TBTO caused a significant reduction of maternal body weight gain and also proved to be highly embryotoxic. Necropsy showed a dose-related decrease in spleen weight while a dose-dependent increase in placental weight was observed.
摘要
妊娠小鼠在妊娠第6至15天用5、20和40毫克/千克/天的双（三正丁基锡）氧化物（TBTO）进行处理，并在妊娠第17天处死。在最高剂量下，TBTO导致母体体重增加显著减少，并且被证明具有高度胚胎毒性。尸检显示脾脏重量呈剂量相关减少，而胎盘重量呈剂量依赖性增加。
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