Kiani Soroosh, Brecht Mary-Lynn, Lovinger Katherine, Poston Robert S
Division of Cardiothoracic Surgery, University of Arizona School of Medicine, Tucson, AZ 85724-5071, USA.
Heart Surg Forum. 2012 Oct;15(5):E272-6. doi: 10.1532/HSF98.20111179.
Robotic-assisted coronary artery bypass grafting (r-CABG) requires the placement of ports bluntly through the chest wall. When removed, these ports create bleeding sites that can be difficult to detect and treat. This study evaluated whether a topical hemostatic agent placed locally within these sites helps to reduce bleeding and blood product requirements.
We retrospectively analyzed outcomes for r-CABG cases where 5 mL of a flowable hemostatic agent was injected locally within all port sites (hemostat group, n = 62) compared with patients whose port sites were untreated (controls, n = 131). Outcomes included chest tube output, red blood cell (RBC) transfusions, length of hospital stay, and the risk of reoperation for bleeding. Analyses were adjusted for risk factors known to influence bleeding and Society of Thoracic Surgeons (STS) risk score as a weighted composite of variables, which controls for patient and clinical variables.
The 2 study groups had similar baseline characteristics and underwent the same r-CABG procedure. The hemostat group had significant reductions in RBC transfusion (24.2% versus 40.8% receiving blood; P = .026; 0.44 versus 1.39 U transfused postoperatively, P = .024). After adjustment for bleeding risks (using STS risk score), differences in transfusions remained significant. Reoperation rates for bleeding, length of stay, chest tube drainage, and intraoperative transfusions were not significantly different in the 2 groups.
There was significantly reduced postoperative bleeding and less exposure to blood products in the hemostat group. These findings suggest that undetected bleeding from sites used for port access serves as an underappreciated source of morbidity after r-CABG.
机器人辅助冠状动脉旁路移植术(r-CABG)需要通过胸壁钝性置入端口。移除这些端口时会形成出血部位,可能难以检测和处理。本研究评估在这些部位局部应用局部止血剂是否有助于减少出血和血液制品需求。
我们回顾性分析了r-CABG病例的结果,其中在所有端口部位局部注射5 mL可流动止血剂的患者为止血剂组(n = 62),与之对比的是端口部位未进行处理的患者(对照组,n = 131)。结果包括胸管引流量、红细胞(RBC)输注情况、住院时间以及因出血再次手术的风险。分析针对已知影响出血的风险因素以及作为变量加权综合指标的胸外科医师协会(STS)风险评分进行了调整,该评分可控制患者和临床变量。
两个研究组具有相似的基线特征,且接受相同的r-CABG手术。止血剂组的RBC输注量显著减少(接受输血者比例为24.2% 对比40.8%;P = .026;术后输注量为0.44 U对比1.39 U,P = .024)。在对出血风险进行调整(使用STS风险评分)后,输血差异仍然显著。两组在出血再次手术率、住院时间、胸管引流以及术中输血方面无显著差异。
止血剂组术后出血显著减少,且接触血液制品较少。这些发现表明,r-CABG术后端口接入部位未被检测到的出血是一个未得到充分重视的发病原因。