基于人工肽序列的高效 HIV 融合抑制剂设计。
Design of highly potent HIV fusion inhibitors based on artificial peptide sequences.
机构信息
Department of Medicinal Chemistry, Beijing Institute of Pharmacology & Toxicology, 27 Taiping Rd, Haidian District, Beijing 100850, China.
出版信息
Chem Commun (Camb). 2012 Dec 7;48(94):11579-81. doi: 10.1039/c2cc35973a.
PMID:23093045
Abstract
Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.
摘要
基于结构的合理设计策略，在设计融合抑制剂时，在人工七肽重复模板和 HIV-1 gp41 之间引入了特定的相互作用。设计的肽与天然存在的肽和蛋白质序列没有同源性，与 HIV-1 gp41 特异性相互作用，并显示出很强的抗 HIV 活性。
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