Müller-Ladner Claudia, Müller-Ladner Ulf
Justus-Liebig Universität Giessen, Abt. Rheumatologie und klinische Immunologie, Kerckhoff Klinik Bad Nauheim, Benekestrasse 2, 61231 Bad Nauheim.
Med Monatsschr Pharm. 2012 Oct;35(10):353-64; quiz 365-6.
Since patients with autoimmune inflammatory rheumatic diseases are prone to infectious complications--on one hand due to the rheumatic disease itself, on the other hand due to the immunosuppressive therapy--vaccination is an essential tool to prevent these infectious complications. Although there exist several recommendations for the vaccination of immunocompromised patients, many questions still remain for the distinct clinical situations of patients with autoimmune inflammatory rheumatic diseases. In addition, there are several questions concerning the safety and efficacy of various vaccinations, especially with regard to live-attenuated vaccines. Therefore, EULAR (European League Against Rheumatism) assembled two expert panels to clarify as much of these clinical problems as possible. After extensive literature review and evidence grading, the expert panels published recommendations for the vaccination of adult and pediatric patients, which are outlined in this review article.
由于自身免疫性炎性风湿性疾病患者容易出现感染性并发症——一方面是由于风湿性疾病本身,另一方面是由于免疫抑制治疗——疫苗接种是预防这些感染性并发症的重要手段。尽管对于免疫功能低下患者的疫苗接种已有多项建议,但对于自身免疫性炎性风湿性疾病患者的不同临床情况,仍存在许多问题。此外,关于各种疫苗接种的安全性和有效性,尤其是减毒活疫苗,也存在若干问题。因此,欧洲抗风湿病联盟(EULAR)组建了两个专家小组,以尽可能澄清这些临床问题。经过广泛的文献综述和证据分级后,专家小组发布了针对成人和儿童患者疫苗接种的建议,本文将对此进行概述。