Siggins G R
Drug Alcohol Depend. 1979 May-Jul;4(3-4):307-19. doi: 10.1016/0376-8716(79)90013-9.
This paper aims to outline some of the caveats inherent in studies on first and second messengers in the central nervous system as related to tolerance and dependence. Analysis of systems based on measures of first and second messengers may be an over-simplification, since the actual molecular consequences of neurotransmission might result in a multilevel cascade of many sequential messages including protein kinase activation and protein phosphorylation and/or dephosphorylation.
本文旨在概述中枢神经系统中与耐受性和依赖性相关的第一信使和第二信使研究中固有的一些注意事项。基于第一信使和第二信使测量的系统分析可能过于简单化，因为神经传递的实际分子后果可能导致包括蛋白激酶激活、蛋白质磷酸化和/或去磷酸化在内的许多连续信息的多级级联反应。
