Breese G R, Lundberg D B, Mailman R B, Frye G D, Mueller R A
Drug Alcohol Depend. 1979 May-Jul;4(3-4):321-6. doi: 10.1016/0376-8716(79)90014-0.
Many psychotropic drugs alter cerebellar cyclic guanosine-3',5'-monophosphate (cGMP) content. Whereas apomorphine increased levels, central depressants such as ethanol, chlordiazepoxide or barbiturates, reduce the content of cerebellar cGMP without altering levels of cyclic adenosine-3',5'-monophosphate (cAMP). Additional data indicate that tolerance develops to this reduction of cerebellar cGMP by ethanol. In paralyzed animals, the increase in cerebellar cGMP content induced by apomorphine and the decrease caused by ethanol were dramatically attenuated. Since relatively high doses of ethanol were needed to decrease blood CO2 tension in spontaneously moving rats, changes in respiratory function appear to be of only minor importance in the ethanol-induced decrease in cerebellar cGMP. It is concluded that ethanol-induced changes in content of cerebellar cGMP in vivo may be secondary to alterations in motor and, to a lesser extent, in respiratory function.
许多精神药物会改变小脑环磷酸鸟苷（cGMP）的含量。阿扑吗啡会使其水平升高，而乙醇、氯氮卓或巴比妥类等中枢抑制剂会降低小脑cGMP的含量，同时不改变环磷酸腺苷（cAMP）的水平。更多数据表明，乙醇对小脑cGMP含量的这种降低会产生耐受性。在瘫痪动物中，阿扑吗啡诱导的小脑cGMP含量增加以及乙醇引起的降低都显著减弱。由于需要相对高剂量的乙醇才能降低自发活动大鼠的血液二氧化碳张力，因此呼吸功能的变化在乙醇诱导的小脑cGMP降低中似乎只起次要作用。结论是，体内乙醇诱导的小脑cGMP含量变化可能继发于运动功能改变，在较小程度上也继发于呼吸功能改变。
