Research Center of Analytical Instrumentation, Analytical & Testing Center, College of Chemistry, Sichuan University, Chengdu, China.
Mass Spectrom Rev. 2013 Mar-Apr;32(2):143-65. doi: 10.1002/mas.21357. Epub 2012 Oct 23.
Proton-transfer reaction mass spectrometry (PTR-MS) allows for real-time, on-line determination of absolute concentrations of volatile organic compounds (VOCs) with a high sensitivity and low detection limits (in the pptv range). The technique utilizes H₃O⁺ ions for proton-transfer reactions with many common VOCs while having little to no reaction with any constituents commonly present in air. Over the past decades, research has greatly improved the applications and instrumental design of PTR-MS. In this article, we give an overview of the development of PTR-MS in recent years and its application in medical research. The theory of PTR-MS and various methods for discriminating isobaric VOCs are also described. We also show several specialized designs of sample inlet system, some of those may make PTR-MS suitable for the detection of aqueous solution and/or non-volatile samples.
质子转移反应质谱（PTR-MS）允许实时、在线测定挥发性有机化合物（VOCs）的绝对浓度，具有高灵敏度和低检测限（在 pptv 范围内）。该技术利用 H₃O⁺离子与许多常见的 VOCs 进行质子转移反应，而与空气中常见的任何成分几乎没有反应。在过去的几十年中，研究极大地改进了 PTR-MS 的应用和仪器设计。在本文中，我们概述了近年来 PTR-MS 的发展及其在医学研究中的应用。还描述了 PTR-MS 的理论和各种鉴别等质量离子 VOCs 的方法。我们还展示了几种专门设计的样品入口系统，其中一些可能使 PTR-MS 适用于水溶液和/或非挥发性样品的检测。
