Department of Cardiology and Pneumology, Göttingen University Medical Centre, Georg August University, Göttingen, Germany.
J Pathol. 2013 Jan;229(2):264-73. doi: 10.1002/path.4120.
The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis.
异常的 CpG 岛启动子甲基化是基因转录有效沉默的主要表观遗传机制。少数选定基因的异常高甲基化在促进纤维化成纤维细胞的激活和驱动纤维化发生中起着重要作用。在这里，我们回顾了 DNA 甲基化和去甲基化的机制及其对成纤维细胞激活和组织纤维化的影响。
