Splinter M Y, Seifert C F, Bradberry J C, Allen L V, Tu Y H, Welsh J D
Department of Pharmacy Services, Oklahoma Memorial Hospital, Oklahoma City.
Am J Hosp Pharm. 1990 Feb;47(2):373-7.
Various methods of administering phenytoin suspension through a percutaneous endoscopic gastrostomy (PEG) Pezzer catheter were evaluated in vitro to determine which method resulted in the most complete recovery of phenytoin. To determine the effect of temperature on phenytoin recovery, 12 mL of phenytoin suspension (Dilantin-125, 125 mg/5 mL) was administered through three separate 35.5-cm 20 French latex PEG Pezzer catheters under each of three temperature conditions (suspension 11.8 degrees C and catheter 22 degrees C, suspension and catheter 22 degrees C, and suspension 22 degrees C and catheter 37 degrees C). To determine the effect of the administration method, 12-mL aliquots of phenytoin suspension were injected into the catheter by seven methods that varied with respect to catheter temperature, dilution of suspension, and irrigation of catheter. Each method was tested in triplicate, and samples were assayed by high-performance liquid chromatography. Varying the temperature of the catheter or suspension had little effect on the recovery of phenytoin. There was no appreciable loss of phenytoin when the suspension was undiluted, regardless of whether the catheter was irrigated. The greatest losses were seen when the suspension was diluted before administration. Irrigation also caused a decrease in recovery, but to a lesser extent than dilution. Until the effects of administering multiple doses of phenytoin through PEG Pezzer catheters are investigated, phenytoin suspension should not be diluted before administration because of decreased recovery and increased administration time.
通过经皮内镜下胃造口术（PEG）佩泽导管给药苯妥英混悬液的各种方法在体外进行了评估，以确定哪种方法能使苯妥英的回收率最高。为了确定温度对苯妥英回收率的影响，在三种温度条件下（混悬液11.8摄氏度且导管22摄氏度、混悬液和导管均为22摄氏度、混悬液22摄氏度且导管37摄氏度），通过三根单独的35.5厘米长的20法式乳胶PEG佩泽导管分别注入12毫升苯妥英混悬液（狄兰汀 - 125，125毫克/5毫升）。为了确定给药方法的影响，通过七种在导管温度、混悬液稀释度和导管冲洗方面各不相同的方法，将12毫升等分的苯妥英混悬液注入导管。每种方法都进行了三次测试，并通过高效液相色谱法对样品进行分析。改变导管或混悬液的温度对苯妥英的回收率影响不大。当混悬液未稀释时，无论导管是否冲洗，苯妥英都没有明显损失。给药前混悬液稀释时损失最大。冲洗也会导致回收率下降，但程度小于稀释。在研究通过PEG佩泽导管多次给药苯妥英的效果之前，由于回收率降低和给药时间增加，苯妥英混悬液在给药前不应稀释。
