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Chiari畸形与中枢性睡眠呼吸暂停:手术治疗后采用适应性压力支持伺服通气的成功治疗

Chiari malformation and central sleep apnoea: successful therapy with adaptive pressure support servo-ventilation following surgical treatment.

作者信息

Fahim Ahmed, Johnson Anthony O C

机构信息

Department of Respiratory Medicine, Pinderfields Hospital, Mid Yorkshire Hospitals, Wakefield, UK.

出版信息

BMJ Case Rep. 2012 Oct 24;2012:bcr-2012-007143. doi: 10.1136/bcr-2012-007143.

Abstract

Sleep apnoea is a common disorder with significant morbidity. It is categorised into obstructive and central sleep apnoea. There are a variety of conditions associated with central sleep apnoea ranging from cardiac failure to structural brain anomalies. We herein report a case of 57-year-old woman with Chiari malformation associated with significant sleep-disordered breathing. There was a family history of Chiari malformation. Although neurosurgical intervention had a significant impact on apnoea hypopnoea index (AHI) with a reduction from 81/h preoperatively to 22.1/h after the surgical treatment, it failed to cure the sleep disorder breathing completely and adaptive non-invasive servo-ventilation had a dramatic effect on symptoms and normalised the AHI. Although, central sleep apnoea is associated with a number of common disorders, this case illustrates that there may be an unusual cause. Moreover, adaptive pressure support servo-ventilation may provide a promising treatment option following surgical correction of Chiari malformation.

摘要

睡眠呼吸暂停是一种常见且具有显著发病率的疾病。它可分为阻塞性和中枢性睡眠呼吸暂停。有多种与中枢性睡眠呼吸暂停相关的病症,从心力衰竭到结构性脑异常不等。我们在此报告一例57岁女性,患有与严重睡眠呼吸紊乱相关的Chiari畸形。存在Chiari畸形家族史。尽管神经外科干预对呼吸暂停低通气指数(AHI)有显著影响,从术前的81次/小时降至手术治疗后的22.1次/小时,但未能完全治愈睡眠呼吸紊乱,而适应性无创伺服通气对症状有显著效果并使AHI恢复正常。虽然中枢性睡眠呼吸暂停与多种常见病症相关,但该病例表明可能存在不寻常的病因。此外,在Chiari畸形手术矫正后,适应性压力支持伺服通气可能提供一种有前景的治疗选择。

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本文引用的文献

10
Sleep apnea in acromegaly.肢端肥大症中的睡眠呼吸暂停。
Ann Intern Med. 1991 Oct 1;115(7):527-32. doi: 10.7326/0003-4819-115-7-527.

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