Seoul National University College of Medicine, 101 Daehang-ro, Chongno-gu, Seoul 110-744, South Korea.
J Geriatr Cardiol. 2012 Sep;9(3):278-84. doi: 10.3724/SP.J.1263.2012.05091.
Percutaneous coronary intervention (PCI) for coronary bifurcation lesions has been associated with lower procedural success rates and worse clinical outcomes compared with PCI for simple coronary lesions. Angiographic evaluation alone is sometimes inaccurate and does not reflect the functional significance of bifurcation lesions. The fractional flow reserve (FFR) is an easily obtainable, reliable, and reproducible physiologic parameter. This parameter is epicardial lesion specific and reflects both degree of stenosis and the myocardial territory supplied by the specific artery. Recent studies have shown that FFR-guided provisional side branch intervention strategy for bifurcation lesions is feasible and effective and can reduce unnecessary complex interventions and related complications. However, an adequate understanding of coronary physiology and the pitfalls of FFR is essential to properly use FFR for PCI of complex bifurcation lesions.
经皮冠状动脉介入治疗（PCI）治疗冠状动脉分叉病变的手术成功率较单纯冠状动脉病变低，临床结局也较差。单独的血管造影评估有时并不准确，不能反映分叉病变的功能意义。血流储备分数（FFR）是一种易于获得、可靠且可重复的生理学参数。该参数与心外膜病变有关，反映了狭窄程度和特定动脉供应的心肌区域。最近的研究表明，FFR 指导的分叉病变边支介入策略是可行和有效的，可以减少不必要的复杂介入治疗及其相关并发症。然而，为了正确地将 FFR 用于复杂分叉病变的 PCI，充分了解冠状动脉生理学和 FFR 的局限性至关重要。
