Godfraind T, Tona Lutete D N
Eur J Pharmacol. 1979 Dec 20;60(4):329-36. doi: 10.1016/0014-2999(79)90237-1.
SC4453 is a digoxin analogue with a pyridazine instead of a lactone ring on C17 beta. SC4453 was compared with digoxin with respect to inhibition of (Na+ + K+)-ATPase prepared from human heart, guinea-pig heart and guinea-pig brain. SC4453 was slightly less potent than digoxin but showed a similar sensitivity to K+. As for cardenolides, species differences in sensitivity to SC4453 were accounted for by differences in the rate of dissociation from the receptors. These observations confirm that the human heart is one of the tissues most sensitive to cardiac glycosides.
SC4453是一种地高辛类似物，其C17β位上是哒嗪环而非内酯环。将SC4453与地高辛在抑制从人心脏、豚鼠心脏和豚鼠大脑制备的（钠+钾）-ATP酶方面进行了比较。SC4453的效力略低于地高辛，但对钾的敏感性相似。至于强心苷，对SC4453敏感性的物种差异是由从受体解离速率的差异造成的。这些观察结果证实，人心脏是对强心苷最敏感的组织之一。
