一种针对人丝氨酸蛋白酶抑制剂B5（SERPINB5）的多功能单克隆抗体。
A versatile monoclonal antibody specific to human SERPINB5.
作者信息
Teoh Sonia S Y, Wang Hong, Risbridger Gail P, Whisstock James C, Bird Phillip I
机构信息
Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria, Australia.
出版信息
Hybridoma (Larchmt). 2012 Oct;31(5):333-9. doi: 10.1089/hyb.2012.0035.
Maspin (SERPINB5) is a member of the Clade B subgroup of the large superfamily of serine protease inhibitors. It is proposed that maspin is a tumor suppressor; however, its molecular role remains to be elucidated. Here we report the characterization of a mouse monoclonal antibody directed against human maspin. This antibody, 16F7, recognizes maspin in both its native and denatured form, unlike several other commercial antibodies tested in this study. It will be a useful and versatile tool for future analyses of the biological function of maspin.
乳腺丝抑蛋白（Maspin，即丝氨酸蛋白酶抑制剂家族B5成员，SERPINB5）是丝氨酸蛋白酶抑制剂大型超家族B进化枝亚组的成员。有人提出乳腺丝抑蛋白是一种肿瘤抑制因子；然而，其分子作用仍有待阐明。在此，我们报告了一种针对人乳腺丝抑蛋白的小鼠单克隆抗体的特性。与本研究中测试的其他几种商业抗体不同，这种名为16F7的抗体能够识别天然和变性形式的乳腺丝抑蛋白。它将成为未来分析乳腺丝抑蛋白生物学功能的一种有用且通用的工具。
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