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法国养老院居民使用苯二氮䓬类药物的指标:一项横断面研究。

Indicators of benzodiazepine use in nursing home residents in France: a cross-sectional study.

机构信息

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.

出版信息

J Am Med Dir Assoc. 2013 Jan;14(1):29-33. doi: 10.1016/j.jamda.2012.09.002. Epub 2012 Oct 23.

Abstract

OBJECTIVES

Little information is available about associations between nursing home (NH) structural and organizational aspects and benzodiazepine prescriptions, particularly for long-acting drugs. This study addressed this knowledge gap.

DESIGN

Cross-sectional study.

SETTING

One hundred seventy-five NHs from France.

PARTICIPANTS

A total of 6275 NH residents, aged 86 years (± 8.2), and mostly women (73.7%).

MEASUREMENTS

Outcome measures were: (1) benzodiazepine and (2) long-acting benzodiazepine use. NH staff sent to research team all drug prescriptions in the week participants were included in the study; staff also recorded information on residents' characteristics, and NHs structure and internal organization. Binary logistic regressions were performed separately on total and long-acting benzodiazepine.

RESULTS

A total of 3350 persons took benzodiazepine; 577 took long-acting benzodiazepine. Subject-related characteristics were the main correlates of benzodiazepine use. NH characteristics were also related to this outcome: number of beds ≥ 91 (Odds Ratio (OR) 0.820, 95% Confidence Interval (CI) 0.682-0.986), special care unit (OR 1.131, 95% CI 1.000-1.279), pharmacy for internal usage (OR 1.341, 95%CI 1.128-1.594), and date records of the first prescription of psychotropics (OR 1.394, 95% CI 1.209-1.607). Pharmacy for internal usage was also associated with long-acting benzodiazepine (OR 1.374, 95% CI 1.076-1.754).

CONCLUSIONS

NH structure- and organization-related indicators impact benzodiazepine use among NH residents. This finding is of particular importance because these indicators are more easily modifiable than subject-related characteristics. Therefore, NH directors and medical staff should be aware about this to implement feasible modifications for reducing inappropriate and chronic benzodiazepine use.

摘要

目的

关于养老院(NH)结构和组织方面与苯二氮䓬类药物处方之间的关联,信息有限,特别是对于长效药物。本研究旨在填补这一知识空白。

设计

横断面研究。

地点

法国 175 家 NH。

参与者

共有 6275 名 86 岁(±8.2 岁)的 NH 居民,其中大多数为女性(73.7%)。

测量

结果指标为:(1)苯二氮䓬类药物和(2)长效苯二氮䓬类药物的使用情况。NH 工作人员将研究期间参与者的所有药物处方发送给研究团队;工作人员还记录了居民特征、NH 结构和内部组织的信息。分别对总苯二氮䓬类药物和长效苯二氮䓬类药物进行二元逻辑回归分析。

结果

共有 3350 人服用苯二氮䓬类药物;577 人服用长效苯二氮䓬类药物。与患者相关的特征是苯二氮䓬类药物使用的主要相关因素。NH 特征也与该结果相关:床位数≥91(优势比(OR)0.820,95%置信区间(CI)0.682-0.986)、特殊护理单元(OR 1.131,95%CI 1.000-1.279)、内部用药药房(OR 1.341,95%CI 1.128-1.594)和精神药物首次处方的日期记录(OR 1.394,95%CI 1.209-1.607)。内部用药药房也与长效苯二氮䓬类药物相关(OR 1.374,95%CI 1.076-1.754)。

结论

NH 结构和组织相关指标会影响 NH 居民的苯二氮䓬类药物使用。这一发现非常重要,因为这些指标比患者相关特征更容易改变。因此,NH 负责人和医务人员应意识到这一点,以便实施可行的修改,以减少不适当和慢性苯二氮䓬类药物的使用。

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