Mongirdiene A, Viezheliene D, Kurshvetene L
Kardiologiia. 2012;52(9):87-93.
Tobacco smoking is a major risk factor of the development of atherosclerosis and thrombosis. Components of tobacco smoke induce changes in the function of thrombocytes, endothelium, macrophages and smooth muscle cells of blood vessels. Smoking causes changes in activity of enzymes of antioxidant system by inducing production of reactive oxygen species. Alterations of cell function and enzyme activity may accelerate formation of atherosclerotic plaques. The compounds of tobacco smoke also promote atherogenesis by affecting gene expression. Aim of the present article is to review published data about molecular mechanisms underlying harmful effects of ingredients of tobacco smoke such as nicotine and tar on the progression of atherosclerosis.
吸烟是动脉粥样硬化和血栓形成的主要危险因素。烟草烟雾的成分会引起血小板、血管内皮、巨噬细胞和血管平滑肌细胞功能的改变。吸烟通过诱导活性氧的产生导致抗氧化系统酶活性的变化。细胞功能和酶活性的改变可能会加速动脉粥样硬化斑块的形成。烟草烟雾中的化合物还通过影响基因表达促进动脉粥样硬化的发生。本文的目的是综述已发表的关于烟草烟雾成分如尼古丁和焦油对动脉粥样硬化进展的有害影响的分子机制的数据。
