昼夜节律：时钟的电冲击。

Circadian rhythms: An electric jolt to the clock.

机构信息

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

出版信息

Curr Biol. 2012 Oct 23;22(20):R876-8. doi: 10.1016/j.cub.2012.08.003.

DOI:10.1016/j.cub.2012.08.003

Abstract

The animal circadian pacemaker is composed of two transcriptional feedback loops, which regulate electrical activity in circadian neurons. Surprisingly, a new study reports that electrical activity can reprogram circadian transcription, and identifies CREB proteins as candidates for this reprograming.

摘要

动物的生物钟由两个转录反馈回路组成，它们调节生物钟神经元的电活动。令人惊讶的是，一项新的研究报告称，电活动可以重新编程生物钟转录，并确定 CREB 蛋白是这种重编程的候选蛋白。