肿瘤诊断和预后中的宿主反应：免疫学家和病理学家联盟的重要性。
Host response in tumor diagnosis and prognosis: importance of immunologists and pathologists alliance.
机构信息
University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
出版信息
Exp Mol Pathol. 2012 Dec;93(3):315-8. doi: 10.1016/j.yexmp.2012.10.013. Epub 2012 Oct 23.
Pathologists and immunologists have collaborated over many years in their efforts to understand and properly diagnose cancer. The ability of pathologists to correctly diagnose this disease was facilitated by the development of immunohistology that utilized specificity of antibodies to distinguish between normal cells and cancer cells. Further boost was provided through the advent of monoclonal antibodies. The two disciplines are now together on the brink of a paradigm shift resulting from a better understanding of the importance for cancer diagnosis and prognosis to consider not only the characteristics of the cancer cells, but also the cancer microenvironment reflecting the host response to the disease. This new immunology and pathology alliance named "Immunoscore" will advance research in both disciplines as well as benefit patients.
多年来，病理学家和免疫学家一直合作，努力理解和正确诊断癌症。免疫组织化学的发展使得病理学家能够正确诊断这种疾病，该技术利用抗体的特异性来区分正常细胞和癌细胞。单克隆抗体的出现进一步推动了这一进程。这两个学科现在共同处于一个范式转变的边缘，这种转变源于对癌症诊断和预后的重要性的更好理解，不仅要考虑癌细胞的特征，还要考虑反映宿主对疾病反应的癌症微环境。这个新的免疫学和病理学联盟被命名为“免疫评分”（Immunoscore），它将推动这两个学科的研究，并使患者受益。
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