Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Invest Ophthalmol Vis Sci. 2012 Nov 21;53(12):7735-45. doi: 10.1167/iovs.12-9952.
To study the choroidal thickness in eyes with inferior posterior staphyloma (IPS) and to elucidate its role in the development of macular complications.
The macular area of 42 eyes of 32 patients with IPS was studied prospectively with swept source optical coherence tomography at 1050 nm. Using a raster scan protocol with 512 × 128 A-scans, we produced a macular choroidal thickness map (6 × 6-mm(2)).
Eyes with IPS showed relatively well-preserved choroid outside of the staphyloma but the inferior-nasal choroid within the staphyloma was thinned substantially. In addition, eyes with IPS often had a belt-shaped area with the thinnest choroid along the superior border of the staphyloma. As patient age increased, choroidal thinning progressed in the entire macular area. The macular choroidal thickness showed a close correlation with age (R(2) = 0.506, P < 0.001). On the superior border of the staphyloma, 13 eyes (30.9%) showed serous retinal detachment and/or pigment epithelial detachment without neovascularization, and eight (19.0%) showed neovascularization. Patients with neovascularization were older and had worse visual acuity (P < 0.001). Macular choroidal thickness in eyes with neovascular complications (76.5 ± 19.9 μm) was significantly reduced compared with that of eyes with no complication (133.0 ± 61.9 μm, P = 0.035).
Eyes with IPS showed marked choroidal thinning along the superior border of the staphyloma. Reduction of the choroidal thickness progressed with age and seemed to be involved in the development of neovascularization associated with the IPS.
研究下斜位后部葡萄肿（IPS）眼的脉络膜厚度，阐明其在黄斑并发症发展中的作用。
前瞻性使用 1050nm 扫频源光学相干断层扫描仪对 32 例 42 只 IPS 眼的黄斑区进行研究。采用 512×128A 扫描的光栅扫描方案，生成黄斑脉络膜厚度图（6×6mm2）。
IPS 眼在葡萄肿外的脉络膜相对保存完好，但葡萄肿内的下鼻侧脉络膜明显变薄。此外，IPS 眼常伴有沿葡萄肿上缘的最薄脉络膜的带状区域。随着患者年龄的增加，整个黄斑区的脉络膜变薄进展。黄斑脉络膜厚度与年龄密切相关（R2=0.506，P<0.001）。在葡萄肿的上缘，13 只眼（30.9%）出现浆液性视网膜脱离和/或色素上皮脱离，无新生血管形成，8 只眼（19.0%）出现新生血管形成。有新生血管形成的患者年龄较大，视力较差（P<0.001）。伴有新生血管并发症的眼的黄斑脉络膜厚度（76.5±19.9μm）明显低于无并发症的眼（133.0±61.9μm，P=0.035）。
IPS 眼沿葡萄肿上缘出现明显的脉络膜变薄。脉络膜厚度的减少随年龄的增长而进展，似乎与 IPS 相关的新生血管形成有关。
