Institute of Keshan Disease, Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, China.
Biol Trace Elem Res. 2013 Jan;151(1):14-7. doi: 10.1007/s12011-012-9530-6. Epub 2012 Oct 26.
The aim of the present study was to explore the role of selenoprotein P (SePP) in the etiology of the endemic sudden cardiac death in Yunnan, China. The levels of SePP of 124 subjects and glutathione peroxidase (GPx) of 119 subjects were measured. The subjects were from the old and new endemic areas and non-endemic areas. The levels of SePP and GPx of the subjects of the old endemic area were significantly higher than those of the subjects of the new endemic area and the non-endemic areas, respectively. The Pearson's correlation among SePP, GPx, and the number of the incident cases of the disease were statistically significant. These correlations show that there is an inverse relationship among the number of patients and the levels of SePP (r = - 0.9800, P = 0.0200) and GPx (r = - 0.961, P = 0.009). The results show that selenium deficiency might play an important role in the incidence of the disease.
本研究旨在探讨硒蛋白 P（SePP）在我国云南地方性猝死病因学中的作用。检测了 124 例研究对象的 SePP 水平和 119 例研究对象的谷胱甘肽过氧化物酶（GPx）水平。这些研究对象来自老疫区、新疫区和非疫区。老疫区研究对象的 SePP 和 GPx 水平明显高于新疫区和非疫区的研究对象，Pearson 相关分析显示 SePP、GPx 与疾病发病例数之间存在显著相关性。这些相关性表明患者人数与 SePP（r = -0.9800，P = 0.0200）和 GPx（r = -0.961，P = 0.009）水平呈负相关。结果表明，硒缺乏可能在疾病的发生中起重要作用。
