鉴定 HCV 感染献血者中的 HCV 基因型。
Identification of HCV genotypes in HCV infected blood donors.
机构信息
Research center, Iranian Blood Transfusion Organization (IBTO), Tehran, Iran.
出版信息
Indian J Microbiol. 2010 Sep;50(3):275-9. doi: 10.1007/s12088-010-0059-0. Epub 2010 Oct 30.
HCV infection is a leading cause of chronic liver disease, including cirrhosis of the liver. There are at least six major genotypes and more than 50 subtypes of HCV. The prevalence and distribution of HCV genotypes depend on geographical location. The aim of this study was to identify and compare the HCV genotypes in HCV infected blood donors and patients. In this cross-sectional study, 167 serum samples from 103 blood donors and 64 patients with hepatitis C were investigated for HCV genotypes. HCV genotyping was carried out using type-specific primers from the core region of the viral genome. The highest frequency was for genotype 1a, with 53 and 34 (51.5% versus 53.1%) of subjects in blood donors and patients respectively. Genotype 3a and 1b were the other frequent genotypes with 4 and 16 (3.9% versus 25%) and 39 and 10 (37.9% versus 15.6%) subjects, respectively. There was not any statistical significant association between the place of infection of the patients and genotype. The results of this study indicate that the distribution of genotypes in the two populations was similar. The dominant HCV genotypes between blood donors and patients were 1a, 3a and 1b respectively.
丙型肝炎病毒（HCV）感染是慢性肝病的主要病因，包括肝硬化。HCV 至少有 6 种主要基因型和 50 多种亚型。HCV 基因型的流行和分布取决于地理位置。本研究旨在鉴定和比较 HCV 感染的献血者和患者的 HCV 基因型。在这项横断面研究中，对 103 名献血者和 64 名丙型肝炎患者的 167 份血清样本进行了 HCV 基因型检测。采用病毒基因组核心区的特异性引物进行 HCV 基因分型。基因型 1a 的频率最高，献血者和患者中分别有 53 和 34 例（51.5%比 53.1%）。基因型 3a 和 1b 也是常见的基因型，分别有 4 和 16 例（3.9%比 25%）和 39 和 10 例（37.9%比 15.6%）。患者感染地点与基因型之间无统计学显著关联。本研究结果表明，两种人群的基因型分布相似。献血者和患者中主要的 HCV 基因型分别为 1a、3a 和 1b。
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