吉非贝齐、地尔硫䓬和硝酸异山梨酯对印度缺血性心脏病患者血脂谱影响的比较研究。
A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India.
作者信息
Sharma H O, Sharma S K
机构信息
Department of Biochemistry, M.P. Shah Medical College, 361 008 Jamnagar, Gujarat.
出版信息
Indian J Clin Biochem. 1997 Dec;12(1):45-8. doi: 10.1007/BF02867954.
Abstract
Effects of three drugs, Gemfibrozil, Diltiazem and lsosorbide dinitrate (ISDN) on various lipid parameters were studied in patients with ischemic heart disease (IHD) with positive treadmill stress response. Gemfibrozil and diltiazem significantly lowered the levels of serum total lipids (TL), triglycerides (TG), phospholipids (PL), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), and incroased the levels of serum high density lipoprotein cholesterol (HDL-C) significantly. However, patients administered with ISDN showed a significant increase in all the lipid parameters except HDL-C, which showed a significant decrease.
摘要
在平板运动应激反应呈阳性的缺血性心脏病（IHD）患者中，研究了吉非贝齐、地尔硫䓬和硝酸异山梨酯（ISDN）这三种药物对各种脂质参数的影响。吉非贝齐和地尔硫䓬显著降低了血清总脂质（TL）、甘油三酯（TG）、磷脂（PL）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）的水平，并显著提高了血清高密度脂蛋白胆固醇（HDL-C）的水平。然而，服用ISDN的患者除HDL-C显著降低外，所有脂质参数均显著升高。
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