Sharma Y D, Fakruddin J M, Bhutani N, Kaushik R, Raina O K, Sharma I
Department of Biotechnology, All India Institute of Medical Sciences, 110029 New Delhi, India.
Indian J Clin Biochem. 1997 Dec;12(Suppl 1):49-51. doi: 10.1007/BF02873057.
Malaria still remains uncontrolled affecting millions and killing many. We have found the high chloroquine-resistance in Rajasthan epidemic which contains multipleP.falciparum strains. Large number of variantP.falciparum strains exist in India which should be taken into account for future malaria control strategies. We have characterised several parasite molecules which are involved in the hostparasite interaction. They can be used to develop the molecular therapy or antimalarial drugs for malaria. The parasite enzymes described by us will be quite useful in this regard, particularly in drug development.
疟疾仍然无法得到控制，影响着数百万人并导致许多人死亡。我们在拉贾斯坦邦的疫情中发现了对氯喹的高抗性，该疫情包含多种恶性疟原虫菌株。印度存在大量变异的恶性疟原虫菌株，未来的疟疾控制策略应予以考虑。我们已经对几种参与宿主 - 寄生虫相互作用的寄生虫分子进行了表征。它们可用于开发疟疾的分子疗法或抗疟药物。我们所描述的寄生虫酶在这方面将非常有用，特别是在药物开发中。
