系统性肥大细胞增多症合并急性粒单核细胞白血病：一例报告
Systemic mastocytosis with acute myelomonocytic leukemia: a case report.
作者信息
Kar Rakhee, Rao Seema, Pati Hara Prasad
机构信息
Department of Hematology, All India Institute of Medical Sciences, New Delhi, 110 029 India.
出版信息
Indian J Hematol Blood Transfus. 2008 Dec;24(4):182-5. doi: 10.1007/s12288-008-0044-5. Epub 2009 Jan 11.
Abstract
Bone marrow mastocytosis may be associated with many clonal non mast cell hematological neoplasms and its association with acute myeloid leukemia especially with t (8; 21) has been described. We describe an interesting case of coexistence of systemic mastocytosis with acute myelomonocytic leukemia in a young child. Diagnosis of acute myelomonocytic leukemia was based on bone marrow aspirate findings coupled with cytochemistry. Systemic mastocytosis was diagnosed on the basis of bone marrow biopsy findings showing blasts as well as multifocal dense mast cell infiltrates with spindling and atypical morphology which was confirmed on toluidine blue staining.
摘要
骨髓肥大细胞增多症可能与许多克隆性非肥大细胞血液系统肿瘤相关，并且其与急性髓系白血病尤其是与t(8;21)的关联已被描述。我们描述了一名幼儿中系统性肥大细胞增多症与急性粒单核细胞白血病共存的有趣病例。急性粒单核细胞白血病的诊断基于骨髓穿刺结果及细胞化学检查。系统性肥大细胞增多症的诊断依据是骨髓活检结果，显示有原始细胞以及多灶性密集的肥大细胞浸润，伴有梭形和非典型形态，甲苯胺蓝染色证实了这一情况。
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