Jouhadi Z, Sadiki H, Lehlimi M, Honsali Z, Najib J, Zerouali K, Belabess H, Mdaghri N
Service de Maladies Infectieuses Pédiatriques, Hôpital d'Enfants, Casablanca, Maroc.
Med Mal Infect. 2012 Dec;42(12):615-8. doi: 10.1016/j.medmal.2012.09.002. Epub 2012 Oct 24.
An increased incidence and severity of invasive group A streptococcus (GAS) infections over the past decade have been reported by several authors, but GAS remains an uncommon cause of bacterial meningitis. The aim of this study was to describe and analyze the clinical and biological data of GAS meningitis by reporting 10 new cases of pediatric GAS meningitis and making a literature review. The mean age of patients, seven girls and three boys, was 3 years. There was a history of preexisting or concomitant community-acquired infection in five patients over 10. The outcome was fatal in two cases. All patients received an initial empirical antimicrobial therapy with a third generation cephalosporin switched in six cases to amoxicillin. The prognosis for this type of streptococcal meningitis is usually good, but death may occur even in children without any identified risk factor for severe infection.
几位作者报告称，在过去十年中侵袭性A组链球菌（GAS）感染的发病率和严重程度有所增加，但GAS仍然是细菌性脑膜炎的罕见病因。本研究的目的是通过报告10例小儿GAS脑膜炎新病例并进行文献综述，来描述和分析GAS脑膜炎的临床和生物学数据。患者平均年龄为3岁，其中7名女孩，3名男孩。超过10名患者中有5名有既往或伴随社区获得性感染史。2例患者死亡。所有患者最初均接受经验性抗菌治疗，使用第三代头孢菌素，其中6例改为阿莫西林。这种类型的链球菌性脑膜炎预后通常良好，但即使在没有任何严重感染风险因素的儿童中也可能发生死亡。
