General Pathology Division of the Oeste Paulista University, Presidente Prudente, SP, Brazil.
Pathol Res Pract. 2012 Dec 15;208(12):699-704. doi: 10.1016/j.prp.2012.08.003. Epub 2012 Oct 24.
The aim this work was to compare the distribution of cellular phenotypes of the LF in the FVC to the ones in the subglottic region in pediatric autopsy, relating this distribution to age and different causes of death. We analyzed 60 larynges of newborns and children autopsied in the period from 1993 to 2003. The fragments were prepared in order to perform histochemical and immunohistochemical techniques. The morphological analysis showed cases that presented LF only in FVC (35%), LF only in the subglottic region (20%), lack of LF in FVC (30%) and lymphoid aggregates, which did not characterize an LF (15%). The cases of LF in the subglottic region were significantly younger compared to the ones that presented LF in the FVC (p=0.017). The LF in the subglottic region was bigger than the LF in the FVC (p=0.020). There was no significant difference between the cause of death and cellular phenotype for both FVC and the subglottic region. In conclusion, the cells that make up the LF in the FVC in newborns and children younger than one year have functional characteristics similar to LF cells in the subglottic region, suggesting that there are similarities with LALT.
本研究旨在比较尸检新生儿和儿童的 FVC 和亚声带区 LF 细胞表型的分布，并将其与年龄和不同死因相关联。我们分析了 1993 年至 2003 年间尸检的 60 例新生儿和儿童的喉。为了进行组织化学和免疫组织化学技术，对这些组织进行了切片。形态学分析显示，仅在 FVC 存在 LF（35%）、仅在亚声带区存在 LF（20%）、FVC 无 LF（30%）和无 LF 的淋巴聚集（15%）。亚声带区 LF 的病例明显比 FVC 中存在 LF 的病例年轻（p=0.017）。亚声带区 LF 比 FVC 中的 LF 大（p=0.020）。FVC 和亚声带区的死因和细胞表型之间没有显著差异。总之，新生儿和 1 岁以下儿童 FVC 中的 LF 细胞具有与亚声带区 LF 细胞相似的功能特征，提示与 LALT 存在相似性。
