Kaiser N, Bourne H R, Insel P A, Coffino P
J Cell Physiol. 1979 Dec;101(3):369-74. doi: 10.1002/jcp.1041010304.
Cyclic AMP (cAMP) causes growth arrest in G1 and induction of cAMP phosphodiesterase and decrease of ornithine decarboxylase in S49 mouse lymphoma cells. Dibutyryl cAMP treatment of partially synchronized cells causes similar changes in activities of both enzymes, regardless of position in the cell cycle. This suggests that cAMP regulation of these enzymes is not mediated by growth perturbation.
环磷酸腺苷（cAMP）可导致S49小鼠淋巴瘤细胞在G1期生长停滞，并诱导cAMP磷酸二酯酶生成，降低鸟氨酸脱羧酶水平。用二丁酰cAMP处理部分同步化的细胞，无论细胞在细胞周期中的位置如何，两种酶的活性都会发生类似变化。这表明cAMP对这些酶的调节不是由生长扰动介导的。
