盐酸匹美西林及盐酸匹美西林胶囊的稳定性指示测定法。
Stability-indicating assay for pivmecillinam hydrochloride and pivmecillinam hydrochloride capsules.
作者信息
Hagel R B, Waysek E H
出版信息
J Chromatogr. 1979 Oct 19;178(1):97-14. doi: 10.1016/s0021-9673(00)89700-9.
PMID:231046
Abstract
A high-pressure liquid chromatographic assay has been developed for pivmecillinam hydrochloride and pivmecillinam hydrochloride capsules. The method separates five reported degradation products and a number of esterified, related compounds. The accuracy of this method is comparable to the published ultraviolet assay and the relative standard deviation of a series of six replicate assays was better than +/- 0.7%.
摘要
已开发出一种用于盐酸匹美西林和盐酸匹美西林胶囊的高压液相色谱测定法。该方法可分离出五种已报道的降解产物以及一些酯化的相关化合物。此方法的准确度与已发表的紫外测定法相当，一系列六次重复测定的相对标准偏差优于±0.7%。
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