使用高效液相色谱法对美西林进行稳定性指示测定。
Stability-indicating assay for mecillinam using high-pressure liquid chromatography.
作者信息
Hagel R B, Waysek E H, Humphrey D
出版信息
J Chromatogr. 1979 Mar 11;170(2):391-8. doi: 10.1016/s0021-9673(00)95465-7.
PMID:232703
Abstract
A high-pressure liquid chromatographic method has been developed for use as a stability-indicating assay for mecillinam. Seven related compounds and at least one unknown degradation product are well separated and easily determined. The accuracy of the method is in good agreement with the published UV assay and the precision of a series of seven replicate determinations is +/- 1.0% R.S.D.
摘要
已开发出一种高压液相色谱法，用作美西林的稳定性指示测定法。七种相关化合物和至少一种未知降解产物得到了很好的分离且易于测定。该方法的准确度与已发表的紫外测定法高度一致，七次重复测定的精密度为±1.0%相对标准偏差。
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